简历－余洁

余洁，博士，副教授，硕士生导师                                 

湖北省“百人计划”创新人才                                  

邮箱: yujie0326@163.com

个人简介：

2020年12月入职武汉轻工大学生命科学与技术学院。2020年10月于澳门大学中华医药研究院获生物医药学博士学位。2015年于西南大学药学院获中药学硕士学位。2012年于湖北中医药大学药学院获药学学士学位。讲授中药学、药学专业英语、现代药学概论等课程。从事中药与天然产物药理研究，中药与天然产物创新药物研发，新型细胞死亡方式与药物作用机理的研究。主持及参与国家自然科学基金项目、澳门科技发展基金项目、国家重点实验室开放课题、湖北省自然科学基金等多项课题。目前发表学术论文近30余篇，其中SCI 收录20余篇。申请发明专利3项，参编中英文著作3部。

主要项目：

1. 湖北省自然基金青年项目，2022CFB885，基于小分子 2-甲氧基-6-乙酰基-7-甲基胡桃酮激活铁死亡抑制耐药非小细胞肺癌作用与机制研究，2022-10 至 2024-9,在研, 主持。

2. 武汉知识创新专项曙光计划项目，2023020201020459，基于肿瘤细胞脂代谢的NQO1底物抗耐药肿瘤作用的分子机制研究，2023-06 至 2025-06，在研，主持。

3. 湖北省教育厅科学研究计划指导性项目, B2021126, 2-甲氧基-6-乙酰基-7-甲基胡桃酮抗恶性脑胶质瘤的作用机制研究, 2021-01 至 2022-12,在研, 主持。

3. 澳门科学技术发展基金, 科研项目, 175/2017/A3 , 基于上皮-间质转化探讨中药之分子机制与治疗意义, 2018-05 至 2021-05,结题, 参与。

4. 澳门科学技术发展基金, 科研项目, 078/2016/A2, 基于程序性坏死探讨中药成分抗肿瘤之作用机制与治疗意义, 2017-03 至 2020-03,结题, 参与。

代表性学术论文：

1. Yu J; Zhong B, Zhao L, Hou Y, Ai N, Lu JJ, Ge W, Chen X. Fighting drug-resistant lung cancer by induction of NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated ferroptosis, drug resistance updates 70 (2023) 100977.

2. Yu J; Zhong B, Zhao L, Hou Y, Wang X, Chen X. Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors Necrostatin-1 (Nec-1) and 7-Cl-O-Nec-1 (Nec-1s) are potent inhibitors of NAD(P)H: Quinone oxidoreductase 1 (NQO1), Free Radical Biology and Medicine, 2021, 173: 64-69.

3. Yu J, Zhong B, Xiao Q, Du L, Hou Y, Sun HS, Lu JJ, Chen X. Induction of programmed necrosis: A novel anti-cancer strategy for natural compounds. Pharmacology & Therapeutics. 2020 May 31:107593.

4. Yu J, Zhong B, Jin L, Hou Y, Ai N, Ge W, Li L, Liu S, Lu JJ, Chen X. 2-Methoxy-6-acetyl-7-methyljuglone (MAM) induced programmed necrosis in glioblastoma by targeting NAD(P)H: Quinone oxidoreductase 1 (NQO1). Free Radical Biology and Medicine. 2020 Mar 28;152:336-347.

5. Sun W, Yu J, Gao H, Wu X, Wang S, Hou Y, Lu JJ, Chen X. Inhibition of Lung Cancer by 2-Methoxy-6-Acetyl-7-Methyljuglone Through Induction of Necroptosis by Targeting Receptor-Interacting Protein 1. Antioxidants & Redox Signaling. 2019 Jul 10;31(2):93-108. co-first author.

6. Yu J, Gao H, Wu C, Xu QM, Lu JJ, Chen X. Diethyl Blechnic, a Novel Natural Product Isolated from Salvia miltiorrhiza Bunge, Inhibits Doxorubicin-Induced Apoptosis by Inhibiting ROS and Activating JNK1/2. International Journal of Molecular Sciences. 2018 Jun 19;19(6).

7. Yu J, Wang C, Kong Q, Wu X, Lu JJ, Chen X. Recent progress in doxorubicin-induced cardiotoxicity and protective potential of natural products. Phytomedicine. 2018 Feb 1;40:125-139.

8. Li J, Yu J, Ma H, Yang N, Li L, Zheng DD, Wu MX, Zhao ZL, Qi HY. Intranasal Pretreatment with Z-Ligustilide, the Main Volatile Component of Rhizoma Chuanxiong, Confers Prophylaxis against Cerebral Ischemia via Nrf2 and HSP70 Signaling Pathways. Journal of Agriculture and Food Chemistry. 2017 Mar 1;65(8):1533-1542. Co-first author.

9. Yu J, Jiang Z, Ning L, Zhao Z, Yang N, Chen L, Ma H, Li L, Fu Y, Zhu H, Qi H. Protective HSP70 Induction by Z-Ligustilide against Oxygen-Glucose Deprivation Injury via Activation of the MAPK Pathway but Not of HSF1. Biological and Pharmaceutical Bulletin. 2015;38(10):1564-72.

10. Zhong B, Yu J, Hou Y, Ai N, Ge W, Lu JJ, Chen X. A novel strategy for glioblastoma treatment by induction of noptosis, an NQO1-dependent necrosis. Free Radic Biol Med. 2021 Apr;166:104-115. doi: 10.1016/j.freeradbiomed.2021.02.014. Epub 2021 Feb 15. PMID: 33600944.

11. Zhong B, Zhao L, Yu J, Hou Y, Ai N, Lu JJ, Ge W, Chen X. Exogenous iron impairs the anti-cancer effect of ascorbic acid both in vitro and in vivo. J Adv Res. 2023 Apr;46:149-158. doi: 10.1016/j.jare.2022.06.011. Epub 2022 Jun 29.

12. Hou Y, Liu R, Xia M, Sun C, Zhong B, Yu J, Ai N, Lu JJ, Ge W, Liu B, Chen X. Nannocystin ax, an eEF1A inhibitor, induces G1 cell cycle arrest and caspase-independent apoptosis through cyclin D1 downregulation in colon cancer in vivo. Pharmacol Res. 2021 Nov;173:105870. doi: 10.1016/j.phrs.2021.105870. Epub 2021 Sep 7. PMID: 34500061.

13. Chen X, Yu J, Zhong B, Lu J, Lu JJ, Li S, Lu Y. Pharmacological activities of dihydrotanshinone I, a natural product from Salvia miltiorrhiza Bunge. Pharmacological Research. 2019 Jul;145:104254.

14. Chen X, Yu J, Shi J. Management of Diabetes Mellitus with Puerarin, a Natural Isoflavone From Pueraria lobata. The American Journal of Chinese Medicine. 2018;46(8):1771-1789.

15. Wu X, Gao H, Hou Y, Yu J, Sun W, Wang Y, Chen X, Feng Y, Xu QM, Chen X. Dihydronortanshinone, a natural product, alleviates LPS-induced inflammatory response through NF-κB, mitochondrial ROS, and MAPK pathways. Toxicology and Applied Pharmacology. 2018 Sep 15;355:1-8.

16. Wu C, Zhao W, Yu J, Li S, Lin L, Chen X. Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells. Scientific Reports. 2018 Jan 12;8(1):574.

17. Kong Q, Ma Y, Yu J, Chen X. Predicted molecular targets and pathways for germacrone, curdione, and furanodiene in the treatment of breast cancer using a bioinformatics approach. Scientific Reports. 2017 Nov 14;7(1):15543.

18. Yuan R, Hou Y, Sun W, Yu J, Liu X, Niu Y, Lu JJ, Chen X. Natural products to prevent drug resistance in cancer chemotherapy: a review. Annals of the New York Academy of Sciences. 2017 Aug;1401(1):19-27.

19. Wu X, Gao H, Sun W, Yu J, Hu H, Xu Q, Chen X. Nepetoidin B, a Natural Product, Inhibits LPS-stimulated Nitric Oxide Production via Modulation of iNOS Mediated by NF-κB/MKP-5 Pathways. Phytotherapy Research. 2017 Jul;31(7):1072-1077.

20. Sun W, Wu X, Gao H, Yu J, Zhao W, Lu JJ, Wang J, Du G, Chen X. Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells. Free Radical Biology and Medicine. 2017 Jul;108:433-444.

21. Li C, Yu J, Lu Y, Wu Q, Shi J, Chen X. Advances in protective effects of tanshinones on cardiovascular and cerebrovascular diseases. Chinese Journal of New Drugs and Clinical Remedies. 2016 Aug:35 (8):0542-0546.

22. Huang, Y., Yu, J., Wan, F., Zhang, W., Yang, H., Wang, L., Qi, H., Wu, C., 2014. Panaxatriol saponins attenuated oxygen-glucose deprivation injury in PC12 cells via activation of PI3K/Akt and Nrf2 signaling pathway. Oxidative Medicine and Cellular Longevity 2014, 978034.

23. Wu, H., Krishnakumar, S., Yu, J., Liang, D., Qi, H., Lee, Z. W., Deng, L. W., Huang, D., Highly selective and sensitive near-infrared-fluorescent probes for the detection of cellular hydrogen sulfide and the imaging of h2s in mice. Chemisitry An Asian Journal. Volume 9, Issue 12, Pages 3604-3611. December 2014.

24. Qi, H. Y., Li, L., Yu, J., Chen, L., Huang, Y. L., Ning, L., Jiang, Z., Yang, N., Xu, X. Y., 2014. Proteomic Identification of Nrf2-Mediated Phase II Enzymes Critical for Protection of Tao Hong Si Wu Decoction against Oxygen Glucose Deprivation Injury in PC12 Cells. Evidence-Based Complementary and Alternative Medicine 2014, 945814. 


25. Li, L., Yang, N., Nin, L., Zhao, Z., Chen, L., Yu, J., Jiang, Z., Zhong, Z., Zeng, D., Qi, H., Xu, X., 2015. Chinese herbal medicine formula Tao Hong Si Wu decoction protects against cerebral ischemia-reperfusion injury via PI3K/Akt and the Nrf2 signaling pathway. Journal Natural Medicines 69, 76-85.

26. Qi, H. Y., Li, L., Yu, J., 2013. Xenohormesis: understanding biological effects of TCM from an evolutionary and ecological perspective, China Journal of Chinese Materia Medica, 3388-3394.

代表性专著：

1. Jie Yu, Li-Da Du, Xiu-Ping Chen, Shou-Bao Wang, Guan-Hua Du, Cissampelini Methiodidum, Nature Small Molecule Drugs from Plants, PEOPLE’S MEDICAL PUBLISHING HOUSE, Springer, page 215-219;

2. Jie Yu, Bingling Zhong, Xiuping Chen, Induction of programmed necrosis by phytochemicals in colorectal cancer, Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Elsevier, page117-133.

3. 余洁,陈修平,《傣肌松》,《天然小分子药物》,人民卫生出版社,page 141-143。 


专利：

1. 2-甲氧基-6-乙酰基-7-甲基胡桃酮的应用。陈修平，葛伟，余洁，钟冰玲。中国专利，公布号：CN 110772503 A。

2. 2-甲氧基-6-乙酰基-7-甲基胡桃酮的新的应用。陈修平，葛伟，余洁，陆金健，钟冰玲。中国专利，公布号：CN 112972442 A。

3. 一种芳香理疗制品及理疗产品。余洁，赵玲，陈新，田微，江维，廖承刚。中国专利，专利号：ZL 2021 2 0989863.1。

奖励：

1. 2022年度湖北省科学进步奖二等奖，食药资源功能因子高效加工技术研发应用。