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张西锋
来源:武汉轻工大学生物与制药工程学院    时间:2014/02/26    编辑:    点击:

张西锋

博士(后) 副教授 硕士生导师

武汉轻工大学生物与制药工程学院

湖北道地药材分子生物学实验室

武汉轻工大学药物研究开发研究中心

武汉市食药兼用资源研究与开发工程技术中心

青岛农业大学生殖科学研究院

青岛农业大学生殖细胞生物学实验室

山东省高校动物生殖与种质创新重点实验室

西北农林科技大学博士,意大利Tor Vergata大学访问学者,韩国Konkuk 大学博士后,中国科学技术大学国内访问学者,中国细胞与分子显微技术学会会员,世界中医药学会联合会会员。主要从事纳米生物技术,细胞生物学和生药学的研究。近年来主持国家自然科学基金青年基金1项,国家自然科学基金面上项目子课题1项,湖北省自然科学基金1项,湖北省教育厅科学技术研究计划重点项目1项,神农架林区科学技术与研发项目1项,山东大学和福建农林大学重点实验室开放课题各1项,武汉轻工大学校立项目1项目;参与国家自然科学基金青年项目2项,湖北省自然科学基金1项,湖北省教育厅科学技术研究计划重点项目1项,山东省农业良种工程项目1项, 基因生物新品种培育重大专项1项。近五年来在"Environ Mol Mutagen","Int J Nanomed","Reprod Fert Develop","Mol Biol Rep","Cell Cycle","Plos One","Appl Environ Microbiol"等期刊上共发表SCI收录论文31篇,其中第一作者或通讯作者22篇;授权国家发明专利2项;获省、市自然科学奖4项。

联系电话: 15607110598 027-83956689(武汉)

15318885978 0532-88030246(青岛)

Email:zhangxf9465@163.com

近年来发表与完成的主要研究论文(“*”为通讯作者):

1. Zhe Han, Qi Yan, Wei Ge, Zhi-Guo Liu, Sangiliyandi Gurunathan, Massimo De Felici, Wei Shen, Xi-Feng Zhang*. Cytotoxic effects of ZnO nanoparticles on mouse testicular cells. Int J Nanomed, 2016, 11:5187-5203.(IF:4.320)

2. Xi-Feng Zhang, Sangiliyandi Gurunathan*. Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: An effective anticancer therapy. Int J Nanomed, 2016, 11:3655-3675.(IF:4.320)

3. Zhang Teng, Shen Wei, De Felici Massimo*, Zhang Xi-Feng*. Di (2-ethylhexyl) phthalate: adverse effects on folliculogenesis that cannot be neglected. Environ Mol Mutagen, 2016, 57(8):579-588. (IF:3.326)

4. Xi-Feng Zhang, Qi Yan, Wei Shen, Sangiliyandi Gurunathan*. Trichostatin A enhances apoptotic potential of palladium nanoparticles in human cervical cancer cells. Int J Mol Sci, 2016, 17(8),1354.(IF:3.257)

5. Xi-Feng Zhang, Wei shen, Sangiliyandi Gurunathan*. Biologically synthesized gold nanoparticles ameliorates cold and heat stress induced oxidative stress in Escherichia coli. Molecules, 2016, 21(6):731.(IF:2.465)

6. Xi-Feng Zhang, Zhi-Guo Liu, Wei Shen, Sangiliyandi Gurunathan*. Silver Nanoparticles: Synthesis, characterization, properties, applications, and therapeutic approaches. Int J Mol Sci, 2016, 17(9):1534.(IF:3.257)

7. Xi-Feng Zhang, Wei Shen, Sangiliyandi Gurunathan*. Silver nanoparticles mediated cellular responses in various cell lines: An in vitro model. Int J Mol Sci, 2016, 17(10): 1603. (IF:3.257)

8. Xi-Feng Zhang, Sangiliyandi Gurunathan*. Bio-fabrication of a novel biomolecule-assisted reduced graphene oxide: An excellent biocompatible nanomaterial. Int J Nanomed, 2016, accepted. (IF:4.320)

9. Wang LQ, Liu JC, Chen CL, Cheng SF, Sun XF, Zhao Y, Yin S, Hou ZM, Pan B, Ding C, Shen W, Zhang XF*. Regulation of primordial follicle recruitment by cross-talk between the Notch and phosphatase and tensin homologue (PTEN)/AKT pathways. Reprod Fert Develop, 2016, 28:700-712.(IF:2.135)

10. Xi-Feng Zhang, Jung-Hyun Park, Yun-Jung Choi, Min-Hee Kang, Sangiliyandi Gurunathan, Jin-Hoi Kim*. Silver nanoparticles cause complications in pregnant mice. Int J Nanomed, 2015,10:7057-7071.(IF:4.320)

11. Xi-Feng Zhang, Sangiliyandi Gurunathan, Jin-Hoi Kim*. Effects of silver nanoparticles on neonatal testis development in mice. Int J Nanomed, 2015,10:6243-6256. (IF:4.320)

12. Zhang XF, Choi YJ, Han JW, Kim E, Park JH, Gurunathan S, Kim JH*. Differential nanoreprotoxicity of silver nanoparticles in male somatic cells and spermatogonial stem cells. Int J Nanomed, 2015,10: 1335-1357. (IF:4.320)

13. Li L, Liu JC, Zhao Y, Lai FN, Yang F, Ge W, Dou CL, Shen W, Zhang XF*, Chen H*. Impact of diethylhexyl phthalate on gene expression and development of mammary glands of pregnant mouse. Histochem Cell Biol, 2015. 144(4):389-402. (IF:2.780)

14. Liang GJ, Zhang XF(co-first authors), Wang JJ, Sun YC, Sun XF, Cheng SF, Li L, De Felicid M, Shen W. ActivinA promote the meiotic initiation of female germ cells in mouse. Stem cell Dev, 2015, 24(20):2455-2465.(IF:3.777)

15. Zhang XF, Zhang T, Han Z, Liu JC, Liu YP, Ma JY, Li L, Shen W*. Transgenerational inheritance of ovarian development deficiency induced by maternal diethylhexyl phthalate exposure. Reprod Fert Develop, 2015,27(8):1213-1221. (IF:2.135)

16. Sun XF, Sun XH, Cheng SF, Wang JJ, Feng YN, Zhao Y, Yin S, Hou ZM, Shen W, Zhang XF*. Interaction of the transforming growth factor-β and Notch signaling pathways in the regulation of granulosa cell proliferation. Reprod Fert Develop, 2015 Jun 3. doi: 10.1071/RD14398. (IF:2.135)

17. Li L, Zhang T, Qin XS, Ge W, Ma HG, Sun LL, Hou ZM, Chen H, Chen P, Qin GQ, Shen W, Zhang XF*. Exposure to Diethylhexyl phthalate (DEHP) results in a heritable modification of imprint genes DNA methylation in mouse oocytes. Mol Biol Rep, 2014, 41(3):1227-1235. (IF:2.024)

18. Zhang XF, Zhang LJ, Li L, Feng YN, Chen B, Ma JM, Huynh E, Shi QH, De Felici M, Shen W. Diethylhexyl Phthalate Exposure Impairs Follicular Developmentand and Affects Oocyte Maturation in the Mouse. Environ Mol Mutagen, 2013, 54(5):354-361. (IF:2.553)

19. Zhang XF, Zhang T, Wang L, Zhang HY, Chen YD, Qin XS, Feng YM, Feng YN, Shen W, Li L. Effects of diethylhexyl phthalate (DEHP) given neonatally on spermatogenesis of mice. Mol Biol Rep, 2013,40(11):6509-6517. (IF:1.958)

20. Zhang GL, Zhang XF(co-first author), Feng YM, Li L, Huynh E, Sun XF, Sun ZY, Shen W*. Exposure to bisphenol A results in a decline of spermatogenesis. Reprod Fert Develop, 2013,25(6):847-859. (IF:2.578)

21. Zhang XF, Zhang LJ, Feng YN, Chen B, Feng YM, Liang GJ, Li L, Shen W*. Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells. Mol Biol Rep, 2012,39 (9): 8621-8628. (IF:2.506)

22. Zhang HQ, Zhang XF(co-first author), Zhang LJ, Chao HH, Pan B, Feng YM, Li L, Sun XF, Shen W*. Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes, Mol Bio Rep,2012, 39(5):5651-5657. (IF:2.506)

授权的国家发明专利:

1 一种茯苓NADPH氧化酶编码基因Nox及其应用,国家发明专利,专利号:ZL 2014 1 0487383.X

2 ActA促进减数分裂前雌性生殖细胞体外发育的技术方法,国家发明专利,专利号:201110341752.0

获奖:

1 沈伟,李兰,孙晓风,张西锋,闵令江. 动物卵母细胞体外发生及其表观遗传调节机制的研究,2012年山东省高等学校优秀科研成果奖(贰等奖),山东省教育厅,2012年12月;

2 沈伟,李兰,孙晓风,张西锋,闵令江. 哺乳动物卵母细胞发生的分子调节机制,青岛市科技进步自然科学类(贰等奖),青岛市人民政府,2013年1月;

3 张腾,张西锋,李兰,朝呼和,张国梁. 2014年山东省研究生优秀科技创新成果三等奖

4 沈伟,张西锋,李兰,孙晓风. 2014年山东高等学校优秀科研成果奖(贰等奖),山东省教育厅,2014年9月.

 

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