个人简介

博士、教授、硕士研究生导师。主要从事智能药物材料方向研究。累计主持/参与国家级、省部级、横向科研项目6项；以第一/通讯作者发表SCI论文40篇，其中TOP 期刊论文18篇；授权第一发明人发明专利4项，多项专利完成成果转化；获省部级市校级科技奖励3项；兼任International Journal of Biological Macromolecules等多个SCI期刊审稿专家、湖北省生物化学会理事等学术职务。长期开展企业技术攻关、成果转化、科技服务工作，完成科技成果转化400于万元，多次入选湖北省中小企业“科技副总”、三区科技人才、科技特派员。

教育经历

2006.09-2010.06 华中科技大学，化学化工学院，无机化学，博士

2003.09-2006.06 华中科技大学，化学化工学院，无机化学，硕士

1999.09-2003.06 山西大同大学，化学教育，本科

工作 / 访学经历

在职任教：2010.07 - 2019.12 武汉轻工大学 生命科学学院 讲师

2020.01 - 2022.12 武汉轻工大学 生命科学学院 副教授

2023.01 - 至今  武汉轻工大学 生命科学学院 教授/副院长

政府挂职：2013.04-2013.12  竹溪县科学技术局，副局长

主要研究方向

智能药物递送材料

基于天然大分子的生物材料

纳米生物递送、生物大分子组装与应用

主持代表性科研项目

1.国家自然科学基金青年项目：基于火棘多糖铁的基因递送载体设计及其用于卵巢癌基因治疗的研究，2017-2019，24万

2.湖北省自然科学基金面上项目：基于单宁酸的四元基因递送系统构建与评价，2020-2021

3.湖北省教育厅科技计划人才项目：基于火棘多糖铁的基因递送载体设计，2016-2017

4.企业横向课题：高纯纳豆激酶冻干粉制备工艺研发，2017-2019

5.企业横向课题：蜂蜜药用辅料制备工艺研究与开发，2024-2025

6.企业横向课题：非小细胞肺癌EGFR靶标依赖性耐药突变联合检测试剂盒研究与开发，2023-2024

7.企业横向课题：藤茶二氢杨梅素高效提取关键技术开发，2020-2022

8.企业横向课题：富硒香料资源高值化加工关键技术研究开发，2023-2024

9.企业横向课题：秦巴地方特色农副资源研究与开发，2021-2022

10.企业横向课题：医用快速止血高分子敷料研究与开发，2025-2026

11.技术许可：高纯度纳豆激酶冻干粉及制剂技术，2022-2032

主持代表性教研项目

1.教育部产学研合作协同育人项目：新工科背景下“人工智能+制药工程”人才协同培养机制研究，2022-2024

2.教育部产学研合作协同育人项目：基于制药⼯程专业特⾊的实践课程体系及教学基地建设与化，2024-2026

代表性学术论文

1.Shuheng Wu, Danni Ni, Yujian Yan, Xianhu Pan, Xin Chen, Jintao Guan, Yuping Bao, Xuemin Xiong, Liang Liu*. Safe and efficient gene delivery based on rice bran polysaccharide. International Journal of Biological Macromolecules, 2019, 137: 1041–1049. (DOI: 10.1016/j.ijbiomac.2019.07.049)通讯作者

2.Liang Liu, Danni Ni, Yujian Yan, Shuheng Wu, Gang Liu. Development of a novel DNA delivery system based on rice bran polysaccharide-Fe(III) complexes. International journal of biological macromolecules. 2019, 142: 600-608. (10.1016/j.ijbiomac.2019.10.001)通讯作者

3.Liang Liu*, Yujian Yan, Danini Ni, Shuheng Wu, Yiran Chen, Xin Chen, Xuemin Xiong, Gang Liu. TAT-functionalized PEI-grafting rice bran polysaccharides for safe and efficient gene delivery. International journal of biological macromolecules. 2020, 146: 1076-1086. (DOI: 10.1016/j.ijbiomac.2019.09.234)通讯作者

4.Liang Liu*, Zhaojun Yang, Chaobing Liu, Mengying Wang, Yiran Chen. Effect of molecular weight of polysaccharide on efficient plasmid DNA delivery by polyethylenimine- polysaccharide-Fe(III) complexes. J Appl Polym Sci. 2022, e53047. (DOI: 10.1002/app.53047)通讯作者

5.Shuheng Wu, Yujian Yan, Dani Ni, Xianhu Pan, Xin Chen, Jintao Guan, Xuemin Xiong, Liang Liu*. Development of a safe and ecient gene delivery system based on a biodegradable tannic acid backbone. Colloids and Surfaces B: Biointerfaces, 2019, 183: 110408. (DOI: 10.1016/j.colsurfb.2019.110408)通讯作者

6.ShengLi Wu, Yifan Zhang, Lichen Wang, Yunjun Mei, Dong Zeng, Yi Wang, Jintao Guan*, Liang Liu*. Resveratrol-modified polyethyleneimine as a high-efficiency and biocompatible gene delivery vector for enhanced transfection. Journal of Drug Delivery Science and Technology, 2025, 113: 107404. (DOI: 10.1016/j.jddst.2025.107404)通讯作者

7.Yiran Chen, Chaobing Liu, Zhaojun Yang, Yanlin Sun, Xin Chen, Liang Liu*. Fabrication of zein-based hydrophilic nanoparticles for efficient gene delivery by layer-by-layer assembly. International journal of biological macromolecules, 2022, 217: 381-397. (DOI: 10.1016/j.ijbiomac.2022.07.042)通讯作者

8.Liang Liu*, Mengying Wang, Chaobing Liu, Zhaojun Yang, Xin Chen. Effective gene delivery based on facilely synthesized "core-shell" Ag@PDA @PEI nanoparticles. J Nanopart Res., 2022, 24: 184. (DOI: 10.1007/s11051-022-05571-8)通讯作者

9.Liang Liu*, Zhaojun Yang, Chaobing Liu, Wang M. Y., Chen X. Preparation of PEI-modified nanoparticles by dopamine self-polymerization for efficient DNA delivery. Biotechnol Appl Biochem., 2022, 1-11. (DOI: 10.1002/bab.2402)通讯作者

10.Liang Liu*, Tiange Wang, Yanlin Sun, Guowei Qi, Jintao Guan, Peiwen Lv , Xin Chen, Dong Zeng. Layer-by-layer nanocomposite based on zein and hyaluronic acid for tumor-targeted gene delivery. Industrial Crops & Products, 2024, 222: 119445. (DOI: 10.1016/j.indcrop.2024.119445)通讯作者

11.Guowei Qi, Jiayu He, Yanlin Sun, Tiange Wang, Yong Shi, Xin Chen, Liang Liu*, Xiaojing Lai. Fabrication of pH responsive variable size hybrid nanocomposites based on zein and LMW-PEI for safe and targeted DNA delivery. Journal of Molecular Liquids, 2025, 421: 126878. (DOI: 10.1016/j.molliq.2025.126878)通讯作者

12.Dong Zeng, Zhiyong He, Jiayu He, Yajing Zhang, Yuqiu Zheng, Yali Li, Mengying Wang, Xiaojing Lai, Liang Liu*. Integration of polyethylenimine functionalized carbon nanotubes nanocarriers for efficient DNA delivery. Bioorganic Chemistry, 2025, 163: 108701. (DOI: 10.1016/j.bioorg.2025.108701)通讯作者

13.Liang Liu*, Chaobing Liu, Zhaojun Yang, Yiran Chen, Xin Chen, Jintao Guan. Dopamine-mimetic-coated polyamidoamine-functionalized Fe3O4 nanoparticles for safe and efficient gene delivery Front. Mater. Sci., 2023, 17(1): 230637. (DOI: 10.1007/s1170602306379)通讯作者

14.Liang Liu*, Yiran Chen, Chaobing Liu, Yujian Yan, Zhaojun Yang, Xin Chen X, Gang Liu. Effect of Extracellular Matrix Coating on Cancer Cell Membrane-Encapsulated Polyethyleneimine/DNA Complexes for Efficient and Targeted DNA Delivery In Vitro. Molecular Pharmaceutics. 2021, 18: 2803-2822. (DOI: 10.1021/acs.molpharmaceut.1c00359)通讯作者

15.Mengying Wang , Yanlin Sun , Mingjie Wang , Zhaojun Yang , Yong Shi , Dong Zeng , Liang Liu*. Enhancing the safety and effectiveness of polyethylenimine gene delivery through cell membrane encapsulation. Journal of Drug Delivery Science and Technology, 2024, 92: 105376. (DOI: 10.1016/j.jddst.2024.105376)通讯作者

16.Liang Liu*, Chaobing Liu, Zhaojun Yang, Yiran Chen, Shuheng Wu, Xin Chen. Safe and efficient DNA delivery based on tannic acid-ion coordination encapsulation. Soft Materials, 2022，(DOI: 10.1080/1539445X.2022.2147945)通讯作者

17.Yanlin Sun, Mengying Wang, Mingjie Wang, Chaobing Liu, Yong Shi, Liang Liu*. The combined plasma membrane coating and cluster bombing strategy for improved tumor-targeting gene delivery of silicon nanoclusters. Colloids and Surfaces B: Biointerfaces. 2023, 231: 113578. (DOI: 10.1016/j.colsurfb.2023.113578)通讯作者

18.Yanlin Sun, Shibei Wang, Mengying Wang, Mingjie Wang, Chaobing Liu, Liang Liu*. Development of a biomimetic DNA delivery system by encapsulating polyethyleneimine functionalized silicon quantum dots with cell membranes. Colloids and Surfaces B: Biointerfaces, 2023, 230: 113507. (DOI: 10.1016/j.colsurfb.2023.113507)通讯作者

19.Mengying Wang, Haoxiang Huang, Yanlin Sun, Mingjie Wang, Zhaojun Yang, Yong Shi, Liang Liu*. PEI functionalized cell membrane for tumor targeted and glutathione responsive gene delivery. International Journal of Biological Macromolecules. 2023, 255: 128354. (DOI: 10.1016/j.ijbiomac.2023.128354)通讯作者

20.Mingjie Wang , Jiayu He , Guowei Qi , Yong Shi , Dong Zeng , Xin Chen , Liang Liu*. Potential applications of PEI loaded graphene oxide quantum dots in safe and efficient DNA delivery. Journal of Drug Delivery Science and Technology, 2024, 101:106146. (DOI: 10.1016/j.jddst.2024.106146)通讯作者

21.Jiayu He, Peng Hu, Mingjie Wang, Guowei Qi, Haoxiang Huang, Dong Zeng, Jintao Guan, Peiwen Lv, Liang Liu*. Utilization of chitosan nanocomposites loaded with quantum dots enables efficient and traceable DNA delivery. Colloids and Surfaces B: Biointerfaces, 2024, 245: 114221. (DOI: 10.1016/j.colsurfb.2024.114221)通讯作者

22.Mingjie Wang , Guowei Qi , Jiayu He , Yuqiu Zheng , Yajing Zhang , Peng Hu, Liang Liu*. Creation of biomimetic polyethylenimine quantum dots nanocomposites for traceable and targeted DNA delivery. Journal of Molecular Liquids, 2024, 408: 125320. (DOI: 10.1016/j.molliq.2024.125320)通讯作者

23.Mingjie Wang, Yuqiu Zheng, Guowei Qi, Yajing Zhang, Shibei Wang, Jiayu He, Xin Chen, Dong Zeng, Liang Liu*. Tannic acid cross-linked polyethylenimine quantum dot nanoclusters for efficient DNA release. International Journal of Biological Macromolecules, 2025, 310: 14. (DOI: 10.1016/j.ijbiomac.2025.143055)通讯作者

24.Tiange Wang, Yanlin Sun, Dong Zeng, Mengying Wang, Yajing Zhang, Gang Liu, Xin Chen, Liang Liu*. Integrated cell membrane encapsulated PQDs-TK quantum dot nanoclusters with ROS-responsive triggering for efficient and visualized DNA delivery. Journal of Colloid And Interface Science, 2025, 683: 393–410. (DOI: 10.1016/j.jcis.2024.12.159)通讯作者

25.Liang Liu*, Guowei Qi, Mingjie Wang, Jiayu He, Yuqiu Zheng, Jintao Guan, Peiwen Lv, Dong Zeng. Construction of intelligent response gene vector based on MOF/Fe3O4/AuNRs for tumor-targeted gene delivery. International Journal of Biological Macromolecules, 2024, 277: 134313. (DOI: 10.1016/j.ijbiomac.2024.134313)通讯作者

26.Jiayu He, Zhipeng Jin, Fengqi Guo, Yali Li, Dong Zeng, Yi Tu, Huaying Liu, Liang Liu*. Traceable pH/near-infrared dual-responsive chitosan quantum dots/polypyrrole nanocarrier for efficient and controllable DNA delivery, International Journal of Biological Macromolecules, 2025, 328, 147693.通讯作者

27.Guowei Qi, Wenjing Lian, Jiayu He, Yuqiu Zheng, Yajing Zhang, Luhong Sun, Xin Chen, Dong Zeng, Huaying Liu, Liang Liu*. Enhancing Deoxyribonucleic Acid Delivery Efficiency via pH-Responsive Metal-Tannic Acid Cross-Linking Encapsulation. Langmuir, 2025, 41(50): 34061-34072. 通讯作者

28.Jiayu He, Yajing Zhang, Yuqiu Zheng, Zhipeng Jin, Mengying Wang, Xin Chen, Gang Liu, Huaying Liu, Dong Zeng, Liang Liu*. Hybridization of CP25k-FA toward Tumor-Targeted Clustered via Glutathione Responsiveness for DNA Delivery, Biomacromolecules, 2025, 26, 6028−6043.通讯作者

29.Yi Tu, Mingjie Wang, Yuqiu Zheng, Dong Zeng, Huaying Liu, Xiaohui Di, Xin Chen, Liang Liu*. Photothermal/GSH-dual-responsive organic quantum dots enabling traceable DNA delivery. International Journal of Biological Macromolecules, 2025, 328: 147542. 通讯作者

授权发明专利

1.刘梁，倪丹妮，陈新，熊学敏. 一种聚乙烯亚胺接枝米糠多糖铁的制备方法及基因载体. 专利号：ZL201910170442.3。

2.刘梁，吴淑恒，陈新，廖荣，熊学敏. 一种以石墨烯为骨架的基因载体及其制备方法. 专利号：ZL201910170441.9。

3.刘梁，燕宇剑，吴淑恒，潘显虎，倪丹妮，关金涛，陈新. ⼀种多巴胺功能化纳⽶银粒⼦的DNA释放载体及其制备方法. 专利号： ZL201910170160.3。

4.潘志勇，孙丹，刘梁. 一种DNA递送载体. 专利号：ZL202510942603.1。

5.刘梁，潘显虎，赵玲，陈新，熊学敏. 一种纳豆激酶冻干粉的制备方法。专利号：ZL201910170506.X 已转化。

指导学生项目及获奖

1.第六届中国国际“互联网+”大学生创新创业大赛湖北省复赛，银奖：纳食髓-高端纳豆健康食品开创者，2020年，游如梦等，指导教师（排1）

2.2021年湖北省第十三届“挑战杯”大学生课外学术科技作品竞赛：基于PEI的基因与药物读书系统的构建，二等奖，2021年，金媛媛等，指导教师（排1）

3.第七届中国国际“互联网+”大学生创新创业大赛湖北省复赛，三等奖：纳食髓-高端纳豆健康食品开创者，2020年，游如梦等，指导教师（排1）

4.湖北省第⼗六届⼤学⽣化学(化⼯)学术创新成果报告会，一等奖：基于硅量⼦点的仿⽣DNA递送载体构建与评价，2023年，郭昌华等， 指导教师（排1）

5.湖北省第⼗五届⼤学⽣化学(化⼯)学术创新成果报告会，二等奖：亲水性蛋白-多糖纳米复合物的制备及其作为基因载体的研究，2022年，王宇等， 指导教师（排1）

6.湖北省第⼗四届⼤学⽣化学(化⼯)学术创新成果报告会，一等奖：多糖铁类基因载体的构建及分子量对其功能的影响，2021年，周钰勤等， 指导教师（排1）

7.湖北省第⼗三届⼤学⽣化学(化⼯)学术创新成果报告会，一等奖：基于单宁酸改性PEI的基因递送体系构建与评价，2020年，黄雨洁等， 指导教师（排1）

科研奖励与人才荣誉

科研成果奖励

1.2022 年，湖北省科技进步二等奖（排4）

2.2020 年，中国商业科技进步奖一等奖（排5）

人才称号 / 个人荣誉

2013，湖北省第二批博士服务团先进个人