韩正刚，博士，副教授，硕士生导师

办公地址：生化楼608 ，食品楼815

联系方式：zhengganghan@whpu.edu.cn；66464546@qq.com

教育经历：2009.11 - 2015.09 Institute of Biochemistry, University of Luebeck, Germany.获自然科学博士学位；2005.9 - 2008.6中国科学院武汉病毒研究所获理学硕士学位；2000.9 - 2005.6沈阳农业大学获动物医学学士学位。

工作经历：2015.11 –至今武汉轻工大学生物与制药工程学院教师；2008.7 - 2009.10香港基因公司市场部武汉产品专员。

研究方向：1)蛋白质结晶与结构解析；2)工业酶催化与转化。

代表性论文与著作：

Yang, J., Ma, T., Shang-Guan, F., & Han, Z. (2020). Improving the catalytic activity of thermostable xylanase from Thermotoga maritima via mutagenesis of non-catalytic residues at glycone subsites. Enzyme and microbial technology, 139, 109579. https://doi.org/10.1016/j.enzmictec.2020.109579

Han, Z., Shang-Guan, F., & Yang, J. (2019). Molecular and Biochemical Characterization of a Bimodular Xylanase From Marinifilaceae Bacterium Strain SPP2. Frontiers in microbiology, 10, 1507. https://doi.org/10.3389/fmicb.2019.01507

Zeng, C., Liu, Z., & Han, Z. (2019). Structure of Staphylococcal Enterotoxin N: Implications for Binding Properties to Its Cellular Proteins. International journal of molecular sciences, 20(23), 5921. https://doi.org/10.3390/ijms20235921

Han, Z., Sakai, N., Böttger, L. H., Klinke, S., Hauber, J., Trautwein, A. X., & Hilgenfeld, R. (2015). Crystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination. Structure (London, England : 1993), 23(5), 882–892. https://doi.org/10.1016/j.str.2015.03.002

Ren, W., Qu, X., Li, W., Han, Z., Yu, M., Zhou, P., Zhang, S. Y., Wang, L. F., Deng, H., & Shi, Z. (2008). Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin. Journal of virology, 82(4), 1899–1907. https://doi.org/10.1128/JVI.01085-07